CHART of ANTIBIOTIC

ANTIBIOTIC CHART

CEPHALOSPORINS

Cefadroxil (Duricef®) 1stCephalexin (Keflex®) 1stCefaclor (Ceclor®) 2ndCefprozil (Cefzil®) 2ndCefuroxime (Ceftin®) 2ndCefdinir (Omnicef®) 3rd

 

Cefditoren (Spectracef®) 3rdCefixime (Suprax®) 3rdCefpodoxime (Vantin®) 3rdCeftibuten (Cedax®) 3rdCeftriaxone (Rocephin®) 3rd

Ceph generations (IV&PO)

 

PENICILLINS

Amoxicillin (Amoxil®)Amoxicillin-clavulanate (Augmentin®)DicloxacillinPenicillin G benzathine (Bicillin L-A®)Penicillin (Pen VK®)

 

MACROLIDES

Azithromycin (Zithromax®)Clarithromycin (Biaxin®)Erythromycin (E.E.S.®)

 

QUINOLONES

Ciprofloxacin (Cipro®)Gemifloxacin (Factive®)Levofloxacin (Levaquin®)Moxifloxacin (Avelox®)Ofloxacin

TETRACYCLINES

DoxycyclineMinocycline (Minocin®)Tetracycline

 

CLINDAMYCIN

Clindamycin (Cleocin®)

 

SULFA MEDICATIONS

Sulfamethoxazole-trimethoprim (Bactrim®)

 

NITROFURANTOIN

Macrobid®Macrodantin®Furadantin®

 

NITROIMIDAZOLES

Metronidazole (Flagyl®)Tinidazole (Tindamax®)

FOSFOMYCIN

Fosfomycin (Monurol®)

 

OXAZOLIDINONES

Linezolid (Zyvox®)

 

OPHTHALMIC ANTIBIOTIC TABLEOTIC ANTIBIOTIC TABLE

 

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Medication	Dosage Form	Dosing	Other
Cefadroxil (Duricef®)	Capsule 500 mg ($) Tablet 1000 mg ($-$$) Suspension 250 mg/5 ml 500 mg/5 ml ($-$$)	Pediatric Impetigo - 30 mg/kg/day (max 1000 mg/day) given once daily or divided into 2 doses (PI) Skin infections - 30 mg/kg/day (max 1000 mg/day) given in 2 divided doses (PI) Strep throat - 30 mg/kg once daily (max 1000 mg/day) for 10 days (IDSA) Urinary tract infection - 30 mg/kg/day (max 1000 mg/day) given in 2 divided doses (PI) Adults Skin infections - 1000 mg/day given once daily or divided into 2 doses (PI) Strep throat - 1000 mg/day given once daily or divided into 2 doses for 10 days (IDSA) Urinary tract infection - 1000 - 2000 mg/day given once daily or divided into 2 doses for 3 - 7 days (IDSA, PI)	Cefadroxil is a first generation cephalosporin May take without regard to food Kidney disease (adults) CrCl < 50 ml/min: dose adjustment recommended; see cefadroxil PI
Cephalexin (Keflex®)	Capsule 250 mg ($) 500 mg ($) 750 mg ($$$$) Tablet 250 mg 500 mg ($) Suspension 125 mg/5 ml 250 mg/5 ml ($)	Pediatric Cellulitis (non-MRSA) - 25 - 50 mg/kg/day (max 2000 mg/day) given in 4 divided doses for 5 - 10 days (IDSA) Endocarditis prophylaxis - 50 mg/kg (max 2000 mg) 30 - 60 minutes before procedure (penicillin allergic without severe reaction) (AHA) Impetigo - 25 – 50 mg/kg/day (max 1000 mg/day) given in 3 – 4 divided doses for 7 days (IDSA) Otitis media - 75 - 100 mg/kg/day given in 4 divided doses for 5 - 10 days (PI) Strep throat - 40 mg/kg/day (max 1000 mg/day) given in 2 divided doses for 10 days (IDSA) Urinary tract infection - 50 - 100 mg/kg/day (max 2000 mg/day) given in 4 divided doses for 7 - 14 days (CTE) Adults (15 years and older) Cellulitis (non-MRSA) - 500 mg 4 times a day for 5 - 10 days (IDSA) Diabetic foot ulcer (mild, non-MRSA) - 500 mg 4 times a day for 7 - 14 days (IDSA) Endocarditis prophylaxis - 2 grams 30 - 60 minutes before procedure (penicillin allergic without severe reaction) (AHA) Impetigo - 250 mg 4 times a day for 7 days (IDSA) Strep throat - 500 mg twice a day for 10 days (IDSA) Urinary tract infection - 500 mg twice a day for 7 days (IDSA, PI) Urinary tract infection, prophylaxis Postcoital - 250 mg one time postcoital (CTE) Continuous - 125 - 250 mg once daily (CTE)	Cephalexin is a first generation cephalosporin May take without regard to food Cephalexin is a first generation cephalosporin Cephalexin may increase metformin levels Kidney disease - clearance is reduced. Manufacturer makes no specific recommendation.
Cefaclor (Ceclor®)	Capsule 250 mg ($) 500 mg ($) Suspension 125 mg/5 ml ($) 250 mg/5 ml ($$-$$$) 375 mg/5 ml ($$-$$$)	Pediatric Cellulitis (non-MRSA) - 20 - 40 mg/kg/day (max 1000 mg/day) given in 3 divided doses (PI) Otitis media - 40 mg/kg/day (max 1000 mg/day) given in 2 divided doses (PI) Pneumonia, community-acquired - 20 - 40 mg/kg/day (max 1000 mg/day) given in 3 divided doses (PI) Strep throat - 20 - 40 mg/kg/day (max 1000 mg/day) given in 2 divided doses for 10 days (PI) Urinary tract infection - 20 - 40 mg/kg/day (max 1000 mg/day) given in 3 divided doses (PI) Adults Cellulitis (non-MRSA) - 250 - 500 mg every 8 hours (PI) Otitis media - 250 - 500 mg every 8 hours (PI) Pneumonia, community-acquired - 500 mg every 8 hours (PI) Strep throat - 250 - 500 mg every 8 hours for 10 days (PI) Urinary tract infection - 250 - 500 mg every 8 hours (PI)	Cefaclor is a second generation cephalosporin Food slows absorption but does not affect the extent of absorption Liver disease - manufacturer makes no dosage recommendation Kidney disease - no dose adjustment necessary
Cefprozil (Cefzil®)	Tablet 250 mg 500 mg ($) Suspension 125 mg/5 ml 250 mg/5 ml ($-$$)	Pediatric (6 months - 12 years) Cellulitis - 20 mg/kg/day (max 1000 mg/day) given once daily for 10 days (PI) Otitis media - 30 mg/kg/day (max 1000 mg/day) given in 2 divided doses for 10 days (PI) Pneumonia, community-acquired - 30 mg/kg/day (max 1000 mg/day) given in 2 divided doses for 7 - 10 days (IDSA) Sinusitis - 15 - 30 mg/kg/day (max 1000 mg/day) given in 2 divided doses for 10 days (PI) Strep throat - 15 mg/kg/day (max 500 mg/day) given in 2 divided doses for 10 days (PI) Adolescents and Adults (age 12 years and older) Cellulitis - 250 - 500 mg twice a day or 500 mg once daily for 10 days (PI) Sinusitis - 250 - 500 mg twice a day for 10 days (PI) Strep throat - 500 mg once daily for 10 days (PI)	Cefprozil is a second generation cephalosporin May take without regard to food Liver disease - no dose adjustment necessary Kidney disease CrCl ≤ 29 ml/min: - use half the standard dose
Cefuroxime (Ceftin®)	Tablet 125 mg 250 mg 500 mg ($) Suspension 125 mg/5 ml 250 mg/5 ml ($$-$$$)	Pediatric (3 months to 12 years) NOTE: Pediatric dosing is for suspension only. Suspension and tablet are not bioequivalent on a mg-to-mg basis. Impetigo - 30 mg/kg/day (max 1000 mg/day) given in 2 divided doses for 10 days (PI) Otitis media - 30 mg/kg/day (max 1000 mg/day) given in 2 divided doses for 5 - 10 days (AAP) Pneumonia, community-acquired - 30 mg/kg/day (max 1000 mg/day) given in 2 divided doses for 7 - 10 days (IDSA) Sinusitis - 30 mg/kg/day (max 1000 mg/day) given in 2 divided doses for a minimum of 10 days (AAP) Strep throat - 20 mg/kg/day (max 500 mg/day) given in 2 divided doses for 10 days (PI) Urinary tract infection - 20 - 30 mg/kg/day (max 1000 mg/day) given in 2 divided doses for 7 - 14 days (CTE) Adolescents and Adults (13 years and older) Bite, animal - Cefuroxime 500 mg twice a day + Clindamycin 300 mg three times a day; OR Metronidazole 250 - 500 mg three times a day (IDSA) Early Lyme disease - 500 mg twice a day for 20 days (PI) Gonorrhea - 1000 mg one time dose (PI) Pneumonia, community-acquired - Cefuroxime 500 mg twice a day for 7 - 14 days + Macrolide (IDSA, PI) Sinusitis - 250 mg twice a day for 10 days (PI) Skin infections - 250 - 500 mg twice a day for 10 days (PI) Strep throat - 250 mg twice a day for 10 days (PI) Urinary tract infection - 250 mg twice a day for 7 days (IDSA, PI)	Cefuroxime is a second generation cephalosporin Suspension should be taken with food Tablets may be taken without regard to food Tablets and suspension are not substitutable on a mg-to-mg basis Kidney disease CrCl ≥ 30 ml/min - no adjustment necessary CrCl 10 - 29 ml/min - give standard individual dose every 24 hours CrCl < 10 ml/min - give standard individual dose every 48 hours
Cefdinir (Omnicef®)	Capsule 300 mg ($) Suspension 125 mg/5 ml 250 mg/5 ml ($)	Pediatric (6 months - 12 years) Otitis media - 14 mg/kg/day (max 600 mg/day) given in 1 or 2 divided doses for 5 - 10 days (AAP) Sinusitis - 14 mg/kg/day (max 600 mg/day) given in 1 or 2 divided doses for a minimum of 10 days (AAP) Skin infections - 7 mg/kg/dose (max 300 mg/dose) twice a day for 10 days (PI) Strep throat - 7 mg/kg/dose (max 300 mg/dose) twice a day for 5 to 10 days OR 14 mg/kg (max 600 mg/day) once daily for 10 days (PI) Adults and Adolescents (Age 13 years and older) Pneumonia, community-acquired - 300 mg twice a day for 10 days (PI) Sinusitis - 300 mg twice a day or 600 mg once daily for 10 days (IDSA) Skin infections - 300 mg twice a day for 10 days (PI) Strep throat - 300 mg twice a day for 5 - 10 days or 600 mg once daily for 10 days (PI) Urinary tract infection - 300 mg twice a day for 3 - 7 days (IDSA)	Cefdinir is a third generation cephalosporin May take without regard to food Iron supplements and antacids reduce cefdinir absorption. Do not take within 2 hours of each other. Cefdinir and iron may cause stool to turn red Liver disease - no dose adjustment necessary Kidney disease CrCl < 30 ml/min: adult dose is 300 mg once daily; pediatric dose is 7 mg/kg/day (max 300 mg/day) given once daily
Cefditoren (Spectracef®)	Tablet 200 mg ($$$$) 400 mg ($$$$)	Adults and Adolescents (Age 12 years and older) Pneumonia, community-acquired - 400 mg twice a day for 14 days (PI) Skin infections - 200 mg twice a day for 10 days (PI) Strep throat - 200 mg twice a day for 10 days (PI)	Cefditoren has been discontinued in the U.S. Cefditoren is a third generation cephalosporin Take with a meal to increase absorption Drugs that reduce gastric acidity (e.g. antacids, H2 blockers, PPIs) decrease absorption Liver disease Child-Pugh A/B: no dose adjustment necessary Child-Pugh C: has not been studied Kidney disease CrCl > 50 ml/min: No dose adjustment necessary CrCl 30 - 49 ml/min: 200 mg twice a day CrCl < 30 ml/min: 200 mg once daily
Cefixime (Suprax®)	Capsule 400 mg ($$$$) Tablet, chewable 100 mg 150 mg 200 mg ($$$$) Tablet 400 mg ($$$$) Suspension 100 mg/5 ml 200 mg/5 ml 500 mg/5 ml ($$$$)	Pediatric (6 months - 12 years) Sinusitis - 8 mg/kg/day (max 400 mg/day) given in one or two divided doses for a minimum of 10 days. Give with clindamycin. See AAP sinusitis recs. (AAP, PI) Urinary tract infection - 8 mg/kg/day (max 400 mg/day) given once daily for 7 - 14 days (CTE) Adults and Adolescents (Age 12 years and older) Gonorrhea - Cefixime - 400 mg single dose + Azithromycin - 1000 mg single dose; OR Doxycycline - 100 mg twice a day for 7 days (CDC)	Cefixime is a third generation cephalosporin May take without regard to food Kidney disease CrCl < 60 ml/min: dose adjustment recommended; see cefixime PI for details
Cefpodoxime (Vantin®)	Tablet 100 mg 200 mg ($$-$$$) Suspension 50 mg/5 ml 100 mg/5 ml ($$-$$$)	Pediatric (age 2 months through 12 years) Otitis media - 10 mg/kg/day (max 400 mg/day) given in 2 divided doses for 5 - 10 days (AAP) Pneumonia, community-acquired - 10 mg/kg/day (max 400 mg/day) given in 2 divided doses for 7 - 10 days (IDSA) Sinusitis - 10 mg/kg/day (max 400 mg/day) given in 2 divided doses for a minimum of 10 days (AAP) Strep throat - 10 mg/kg/day (max 200 mg/day) given in 2 divided doses for 5 - 10 days (PI) Urinary tract infection - 10 mg/kg/day (max 400 mg/day) given in 2 divided doses for 7 - 14 days (CTE) Adolescents and Adults (age 12 years and older) Gonorrhea - 200 mg one time dose (PI) Pneumonia, community-acquired - Cefpodoxime 200 mg twice a day for 7 - 14 days + Macrolide (IDSA, PI) Sinusitis - 200 mg twice a day for 10 days (PI) Skin infections - 400 mg twice a day for 7 - 14 days (PI) Strep throat - 100 mg twice a day for 5 - 10 days (PI) Urinary tract infection - 100 mg twice a day for 3 days (IDSA, CTE)	Cefpodoxime is a third generation cephalosporin Suspension may be taken without regard to food Tablets should be taken with food Drugs that reduce gastric acidity (e.g. antacids, H2 blockers, PPIs) decrease absorption Liver disease - no dose adjustment necessary Kidney disease CrCl < 30 ml/min: increase dosing interval to every 24 hours
Ceftibuten (Cedax®)	Capsule 400 mg ($$$-$$$$) Suspension 180 mg/5 ml ($$$$)	Pediatric Otitis media - 9 mg/kg/day (max 400 mg/day) given once daily for 10 days (PI) Strep throat - 9 mg/kg/day (max 400 mg/day) given once daily for 10 days (PI) Adolescents and Adults (age 12 years and older) Otitis media - 400 mg once daily for 10 days (PI) Strep throat - 400 mg once daily for 10 days (PI)	Ceftibuten has been discontinued in the U.S. Ceftibuten is a third generation cephalosporin Ceftibuten should be taken at least 2 hours before or one hour after a meal. Food decreases absorption. Liver disease - manufacturer makes no dosage recommendation Kidney disease CrCl > 50 ml/min: No dose adjustment necessary CrCl 30 - 49 ml/min: 4.5 mg/kg/day or 200 mg once daily CrCl 5 - 29 ml/min: 2.25 mg/kg/day or 100 mg once daily
Ceftriaxone (Rocephin®)	Vial 250 mg 500 mg 1000 mg 2000 mg ($)	Pediatric E. coli, enterotoxigenic - 50 mg/kg/day IM/IV given once daily for 3 days (CTE) Endocarditis prophylaxis - 50 mg/kg (max 1000 mg) IM 30 - 60 minutes before procedure (AHA) Otitis media - 50 mg/kg/day (max 1000 mg) IM for 1 to 3 days (AAP) Pneumonia, community-acquired - 50 - 100 mg/kg/day (max 2000 mg/day) IM given once daily for 7 - 10 days (IDSA) Salmonella, nontyphoidal - 100 mg/kg/day IV given in 2 divided doses for 7 - 10 days (CTE) Shigella - 50 mg/kg/day IM/IV given once daily for 3 days (CTE/IDSA) Skin infections - 50 - 75 mg/kg/day (max 2000 mg/day) given once a day or in two divided doses (PI) Vibrio vulnificus - 50 mg/kg/day IM/IV given once daily for 3 days (CTE) Adult Diabetic foot ulcer (moderate, non-MRSA) - 1 - 2 gram(s) IM once daily for 7 - 14 days (IDSA, PI) Endocarditis prophylaxis - 1 gram IM 30 - 60 minutes before procedure (AHA) Epididymitis (likely caused by chlamydia or gonorrhea) Ceftriaxone250 mg IM single dose + Doxycycline 100 mg twice a day for 10 days (CDC) Gonorrhea - Ceftriaxone 250 mg IM single dose + Azithromycin - 1000 mg single dose; OR Doxycycline - 100 mg twice a day for 7 days (CDC) Neurosyphilis (pen-allergic) - 2 grams IM/IV daily for 10 - 14 days (CDC) Pneumonia, community-acquired - Ceftriaxone 1 gram IM/IV once daily for 7 - 14 days + Macrolide (IDSA, CTE) Salmonella, nontyphoidal - 1 - 2 gram(s) IV once daily for 5 - 10 days (CTE/IDSA) Syphilis (primary and secondary, pen-allergic) - 1 gram IM/IV daily for 10 - 14 days (CDC)	Ceftriaxone is a third generation cephalosporin Do not give to neonates ≤ 28 days old with hyperbilirubinemia Liver disease - no dose adjustment necessary Kidney disease - no dose adjustment necessary Kidney and liver disease (concurrent) - do not exceed 2 grams daily

Medication	Dosage Form	Dosing	Other
Clindamycin (Cleocin®)	Capsule 75 mg 150 mg 300 mg ($) Solution 75 mg/5 ml ($$) Vaginal cream 2%, 40 gm tube ($-$$) Vaginal suppository 100 mg ($$$) Topical See Topical derm chart	Pediatric Cellulitis (MRSA coverage) - 30 - 40 mg/kg/day (max 1800 mg/day) given in 3 divided doses for 5 - 10 days (IDSA) Endocarditis prophylaxis - 20 mg/kg (max 600 mg) 30 - 60 minutes before procedure (penicillin allergic) (AHA) Impetigo - 20 mg/kg/day (max 1600 mg/day) given in 3 divided doses for 7 days (IDSA) Otitis media - 30 – 40 mg/kg/day (max 1800 mg/day) given in 3 divided doses for 5 - 10 days (AAP) Sinusitis - 8 - 12 mg/kg/day divided into 3 or 4 equal doses for a minimum of 10 days. Give with Cefixime (Suprax®). See AAP sinusitis recs. (AAP, PI) Strep throat - 7 mg/kg/dose (max 300 mg/dose) three times daily for 10 days (IDSA) Adults Bacterial vaginosis Clindamycin vaginal cream 2% - one full applicator (5g) intravaginally at bedtime for 7 days (CDC) Clindamycin oral - 300 mg twice a day for 7 days (CDC) Clindamycin vaginal suppository - 100 mg intravaginally once at bedtime for 3 days (CDC) Bite, animal - Clindamycin - 300 mg three times a day + Cefuroxime (Ceftin®) - 500 mg twice a day; OR Levofloxacin (Levaquin®) - 750 mg once daily; OR Sulfamethoxazole-trimethoprim - 800/160 twice a day (IDSA) Cellulitis (MRSA coverage) - 300 - 450 mg four times a day for 5 - 10 days (IDSA) Diabetic foot ulcer (mild) - 300 - 450 mg four times a day for 7 - 14 days (IDSA) Diabetic foot ulcer (moderate) - Clindamycin 300 - 450 mg four times a day + Ciprofloxacin 500 mg twice a day for 7 - 14 days; OR Levofloxacin 750 mg once daily for 7 - 14 days (IDSA) Endocarditis prophylaxis - 600 mg 30 - 60 minutes before procedure (penicillin allergic) (AHA) Hidradenitis suppurativa - Clindamycin 300 mg twice a day + Rifampin 600 mg once daily for 10 weeks (19590173); also topical clindamycin applied twice a day (CTE) Impetigo - 300 - 400 mg four times a day for 7 days (IDSA) Pseudofolliculitis barbae - Benzoyl peroxide + topical clindamycin applied twice a day (CTE) Strep throat - 300 mg three times a day for 10 days (IDSA)	May take without regard to food Liver disease - dose adjustment not likely necessary Kidney disease - no dose adjustment necessary

Medication	Dosage Form	Dosing	Other
Fosfomycin (Monurol®)	Powder 3 gram packet ($$)	Adults Urinary tract infection - 3 gram packet one time dose (IDSA, PI) Urinary tract infection, prophylaxis - 3 gram packet every 10 days (CTE)	May take without regard to food Mix packet with 3 - 4 ounces of water Kidney disease - clearance is decreased. Manufacturer makes no specific recommendation.

Medication	Dosage Form	Dosing	Other/Recent studies
Azithromycin (Zithromax®)	Tablet 250 mg 500 mg 600 mg ($) Suspension 100 mg/5 ml 200 mg/5 ml ($) Packet of powder 1000 mg ($-$$) Suspension, extended-release (Zmax®) 2 grams/bottle ($$$) Ophthalmic See Conjunctivitis	Pediatric (6 months to 12 years) Campylobacter - 10 mg/kg/day (max 500 mg/day) given once daily for 3 - 5 days (CTE) Cat scratch disease < 45 kg - 10 mg/kg (max 500 mg) on Day 1 followed by 5 mg/kg/day (max 250 mg/day) on Days 2 - 5 > 45 kg - 500 mg on Day 1 followed by 250 mg once daily on Days 2 - 5 (IDSA) E. coli, enterotoxigenic - 10 mg/kg/day (max 500 mg/day) given once daily for 3 days (CTE) Endocarditis prophylaxis -15 mg/kg (max 500 mg) 30 - 60 minutes before procedure (penicillin allergic) (AHA) Pneumonia, community-acquired, atypical - 10 mg/kg (max 500 mg) on Day 1 followed by 5 mg/kg/day (max 250 mg/day) given once daily on Days 2 - 5 (IDSA) Salmonella (nontyphoidal) - 20 mg/kg/day (max 500 mg/day) given once daily for 7 days (CTE) Shigella - 10 mg/kg/day (max 500 mg/day) given once daily for 3 days (CTE) Strep throat - 12 mg/kg/day (max 500 mg/day) given once daily for 5 days (IDSA) Vibrio vulnificus - 10 mg/kg/day (max 500 mg/day) given once daily for 3 days (CTE) Adolescents and Adults Campylobacter - 500 mg once daily for 3 days (CTE) Cat scratch disease - 500 mg on day 1 followed by 250 mg for 4 additional days (IDSA) Chlamydia - 1000 mg single dose (CDC) E. coli, enterotoxigenic - 1000 mg given as a single dose (CTE) Gonorrhea Azithromycin 1000 mg single dose + ceftriaxone 250 mg IM single dose (CDC, preferred) Azithromycin 1000 mg single dose + cefixime 400 mg single dose (CDC, alternative) Azithromycin 2000 mg single dose + gemifloxacin 320 mg single dose (based on PMID 25031289) Azithromycin 2000 mg single dose + gentamicin 240 mg IM single dose (based on PMID 25031289) Endocarditis prophylaxis - 500 mg 30 - 60 minutes before procedure (penicillin allergic) (AHA) Mycoplasma genitalium - 1000 mg one time dose (CDC) Pneumonia, community-acquired Azithromycin - 500 mg on Day 1 followed by 250 mg once daily on Days 2 - 5 (IDSA, PI) Extended-release (Zmax®) - 2000 mg one time dose (PI) Prostatitis, chronic - 500 mg once daily for 4 - 6 weeks (CTE) Salmonella (nontyphoidal) - 500 mg once daily for 7 days (CTE) Shigella - 500 mg once daily for 3 days (CTE) Strep throat - 500 mg once daily for 5 days (IDSA) Syphilis (primary and secondary, pen-allergic) - 2000 mg single dose (CDC) Vibrio vulnificus - 500 mg once daily for 3 days (CTE)	Other May take without regard to food Do not take with aluminum or magnesium antacids Kidney disease CrCl > 10 ml/min: no dose adjustment necessary CrCl < 10 ml/min: use caution Recent studies Macrolide use in pregnancy and risk of birth defects [PMID 26513406]
Clarithromycin (Biaxin®)	Tablet 250 mg 500 mg ($) Tablet, extended-release (Biaxin XL®) 500mg ($-$$) Suspension 125 mg/5 ml 250 mg/5 ml ($$)	Pediatric Endocarditis prophylaxis - 15 mg/kg (max 500 mg) 30 - 60 minutes before procedure (penicillin allergic) (AHA) H. pylori - Clarithromycin - 20 mg/kg/day (max 1000 mg/day) given in 2 divided doses + Amoxicillin - 50 mg/kg/day (max 2000 mg/day) given in 2 divided doses + Proton Pump Inhibitor (PPI) (CTE) DURATION: 10 - 14 days H. pylori, sequential therapy - see H. pylori treatment Pneumonia, community-acquired, atypical - 15 mg/kg/day (max 1000 mg/day) given in 2 divided doses for 7 - 10 days (IDSA) Strep throat - 15 mg/kg/day (max 500 mg/day) given in 2 divided doses for 10 days (IDSA) Adults Endocarditis prophylaxis - 500 mg 30 - 60 minutes before procedure (penicillin allergic) (AHA) H. pylori - Clarithromycin - 500 mg twice a day + Proton Pump Inhibitor (PPI) + Amoxicillin - 1000 mg twice a day; OR Metronidazole - 500 mg twice a day (ACG) DURATION: 10 - 14 days H. pylori, sequential therapy - see H. pylori treatment Pneumonia, community-acquired Standard-release - 250 mg twice a day for 7 - 14 days (IDSA, PI) Extended-release - 1000 mg once daily for 7 days (IDSA, PI) Prostatitis, chronic - 500 mg twice a day for 4 - 6 weeks (CTE) Sinusitis Standard-release - 500 mg twice a day for 14 days (PI) Extended-release - 1000 mg once daily for 14 days (PI) Skin infections - 250 mg twice a day for 7 - 14 days (PI) Strep throat - 250 mg twice a day for 10 days (IDSA)	Other Standard-release tablet and suspension may be taken without regard to food. Extended-release tablets should be taken with food. Clarithromycin is a Strong CYP3A4 inhibitor Liver disease - no dose adjustment necessary Kidney disease CrCl < 30 ml/min: - reduce dose by 50% Recent studies Macrolide use in pregnancy and risk of birth defects [PMID 26513406]
Erythromycin (Eryc®) (E.E.S.®) (Eryped®)	Erythromycin base Capsule, enteric coated (Eryc®) 250 mg ($$-$$$) Tablet, enteric coated (Ery-tab®) 250 mg 333 mg 500 mg ($$$-$$$$) Tablet, enteric coated (PCE®) 333 mg 500 mg ($$-$$$) Tablet 250 mg 500 mg ($$-$$$$) Ophthalmic See Conjunctivitis Topical See Topical derm meds Erythromycin Ethylsuccinate Tablet (E.E.S.®) 400 mg ($$$-$$$$) Granule (E.E.S.®, Eryped®) 200 mg/5 ml 400 mg/5 ml ($$$$) Suspension (E.E.S.®, Pediamycin®) 200 mg/5 ml 400 mg/5 ml ($$$$) Erythromycin Stearate Tablet 250 mg	Pediatric Campylobacter Erythromycin base - 30 mg/kg/day given in 2 - 4 divided doses for 3 - 5 days (CTE) Impetigo Erythromycin ethylsuccinate - 40 mg/kg/day (max 1600 mg/day) given in 3 – 4 divided doses for 7 days (IDSA) Pneumonia, community-acquired, atypical Erythromycin ethylsuccinate - 40 mg/kg/day (max 1600 mg/day) given in 4 divided doses for 7 - 10 days (IDSA) Adolescents and adults Acne Erythromycin base - 250 - 500 mg once daily or 250 - 500mg twice a day (AAP) Campylobacter Erythromycin base - 500 mg two to four times a day for 3 - 5 days (IDSA/CTE) Chlamydia Erythromycin base - 500 mg four times a day for 7 days (CDC) Erythromycin ethylsuccinate - 800 mg four times a day for 7 days (CDC) Impetigo Erythromycin base - 250 mg four times a day for 7 days (IDSA) Erythromycin ethylsuccinate - 400 mg four times a day for 7 days (IDSA) Pneumonia, community-acquired Erythromycin base - 500 mg four times a day or 1000 mg twice a day for 7 - 14 days (IDSA, CTE) [2] Erythromycin ethylsuccinate - 800 mg four times a day or 1600 mg twice a day for 7 - 14 days	Other May take without regard to food 400 mg of erythromycin ethylsuccinate is equivalent to 250 mg of erythromycin base or stearate Erythromycin is a Moderate CYP3A4 inhibitor Liver disease - use caution. Manufacturer makes no specific recommendation. Kidney disease - erythromycin is mostly excreted in the bile. Manufacturer makes no specific recommendation. Recent studies Macrolide use in pregnancy and risk of birth defects [PMID 26513406]

Medication	Dosage Form	Dosing	Other
Nitrofurantoin (Macrobid®) (Macrodantin®) (Furadantin®)	Nitrofurantoin monohydrate : Nitrofurantoin macrocrystalline Capsule, Macrobid® 75 mg : 25 mg ($) Nitrofurantoin macrocrystalline Capsule, Macrodantin® 25 mg 50 mg 100 mg ($) Nitrofurantoin Suspension, Furadantin® 25 mg/5 ml ($$$$)	Pediatric (one month and older) Urinary tract infection Macrodantin® and Furadantin® - 5 - 7 mg/kg/day given in 4 divided doses for 7 days (PI) Urinary tract infection, prophylactic Macrodantin® and Furadantin® - 1 - 2 mg/kg/day given once daily (CTE) Adults Urinary tract infection Macrobid® - 100 mg twice a day for 5 days (IDSA) Macrodantin® - 50 - 100 mg 4 times a day for 7 days (PI) Urinary tract infection, prophylaxis Postcoital - 50 - 100 mg one time postcoital (Macrobid® or Macrodantin®) (CTE) Continuous - 50 - 100 mg once daily (Macrobid® or Macrodantin®) (CTE)	Take with food Do not take with antacids containing magnesium Nitrofurantoin has been associated with rare cases of interstitial lung disease in patients who took it for ≥ 6 months Kidney disease CrCl < 60 ml/min: - do not use

Medication	Dosage Form	Dosing	Other
Metronidazole (Flagyl®)	Capsule 375 mg ($$) Tablet 250 mg 500 mg ($) Tablet, extended-release (Flagyl® ER) 750 mg ($$$$) Topical See topical derm meds	Pediatric Clostridium difficile - 7.5 mg/kg/dose (max 500 mg/dose) given 3 times a day for 10 - 14 days (CTE) Entamoeba histolytica - 35 - 50 mg/kg/day (max 2250 mg/day) given in 3 divided doses for 10 days (PI) Giardia - 5 mg/kg/dose (max 250 mg/dose) given 3 times a day for 7 - 10 days (CTE) H. pylori - Metronidazole - 20 mg/kg/day (max 1000 mg/day) given in 2 divided doses + Amoxicillin - 50 mg/kg/day (max 2000 mg/day) given in 2 divided doses + Proton Pump Inhibitor (PPI) (CTE) DURATION: 10 - 14 days H. pylori, sequential therapy - see H. pylori treatment Adults Bacterial vaginosis Metronidazole - 500 mg twice a day for 7 days (CDC) Metronidazole gel 0.75% - one full applicator (5g) intravaginally once daily for 5 days (CDC) Metronidazole extended-release - 750 mg once daily for 7 days (PI) Bite, animal - Metronidazole - 250 - 500 mg three times a day + Cefuroxime - 500 mg twice a day; OR Levofloxacin - 750 mg once daily; OR Sulfamethoxazole-trimethoprim - 800/160 twice a day (IDSA) Bite, human - Metronidazole - 250 - 500 mg three times a day + Levofloxacin - 750 mg once daily; OR Ciprofloxacin - 500 mg - 750 mg twice a day (IDSA) Clostridium difficile - 500 mg three times a day for 10 - 14 days (IDSA) Diverticulitis - Metronidazole - 500 mg three to four times a day + Ciprofloxacin - 500 mg twice a day; OR Levofloxacin - 750 mg once daily; OR Sulfamethoxazole-trimethoprim - 800/160 twice a day DURATION: 7 - 14 days Entamoeba histolytica - 750 mg three times a day for 5 - 10 days (IDSA/CTE) Giardia - 250 mg - 750 mg three times a day for 7 - 10 days (IDSA); OR 500 mg twice a day for 5 - 7 days (CTE) H. pylori - Metronidazole - 500 mg twice a day + Clarithromycin - 500 mg twice a day + Proton Pump Inhibitor (PPI) (ACG) DURATION: 10 - 14 days H. pylori, sequential therapy - see H. pylori treatment Trichomoniasis - 2000 mg single dose; OR 500 mg twice a day for 7 days (CDC)	May take standard-release without regard to food. Extended-release should be taken one hour before or 2 hours after meals. Potential for disulfiram-like reaction if taken with alcohol. Do not ingest alcohol during, or for 3 days after stopping metronidazole. Liver disease Mild to moderate (Child-Pugh A/B):no dose adjustment necessary Severe (Child-Pugh C): reduce dose by 50% Kidney disease - patients with end-stage renal disease may have decreased clearance. Manufacturer makes no specific recommendation.
Tinidazole (Tindamax®)	Tablet 250 mg 500 mg ($-$$)	Pediatric (3 years and older) Entamoeba histolytica - 50 mg/kg/day (max 2000 mg/day) given once daily for 3 days (PI) Giardia - 50 mg/kg (max 2000 mg) given as a one time dose (PI) Adults Bacterial vaginosis 2000 mg once daily for 2 days (CDC) 1000 mg once daily for 5 days (CDC) Entamoeba histolytica - 2000 mg once daily for 3 days (PI) Giardia - 2000 mg given as a one time dose (CTE/PI) H. pylori, sequential therapy - see H. pylori treatment Trichomoniasis - 2000 mg single dose (CDC)	Take with food to minimize stomach upset Tinidazole is a CYP3A4 sensitive substrate Potential for disulfiram-like reaction if taken with alcohol. Do not ingest alcohol during, or for 3 days after stopping tinidazole. Liver disease - use caution. Manufacturer makes no specific recommendation. Kidney disease - no dose adjustment necessary

Medication	Dosage Form	Dosing	Other/Recent studies
Linezolid (Zyvox®)	Tablet 600 mg ($$$$) Suspension 100 mg/5 ml ($$$$)	Pediatric Cellulitis (MRSA coverage) < 5 years old - 10 mg/kg/dose every 8 hours for 5 - 10 days (IDSA, PI) 5 - 11 years old - 10 mg/kg/dose (max 600 mg/dose) twice a day for 5 - 10 days (IDSA, PI) Pneumonia, community-acquired < 12 years old - 30 mg/kg/day given in 3 divided doses for 7 - 10 days (IDSA) ≥ 12 years old - 20 mg/kg/day (max 1200 mg/day) given in 2 divided doses for 7 - 10 days (IDSA) Adults (12 years and older) Cellulitis (MRSA coverage) - 600 mg twice a day for 5 - 10 days (IDSA) Diabetic foot ulcer (moderate, MRSA coverage) - 400 - 600 mg twice a day for 7 - 14 days (IDSA) Pneumonia, community-acquired - 600 mg twice a day for 10 - 14 days (PI)	Other May take without regard to food Linezolid is a reversible, nonselective MAO inhibitor Do not take within 2 weeks of other MAO inhibitors May increase pressor effect of adrenergic agents including pseudoephedrine and phenylpropanolamine. Foods containing tyramine should also be avoided in large quantities (e.g. aged cheeses, fermented or air-dried meats, sauerkraut, soy sauce, tap beers, and red wines) Has been associated with serotonin syndrome. Use caution when taken with antidepressants and other serotonergic drugs. Liver disease Mild to moderate (Child-Pugh A/B):no dose adjustment necessary Severe (Child-Pugh C): has not been evaluated Kidney disease - no dose adjustment necessary Studies Linezolid susceptibility testing 2014 - 6,865 Gram-positive pathogens from 36 states collected in 2014 were tested for susceptibility to linezolid RESULTS: Linezolid demonstrated excellent activity and a sustained susceptibility rate of 99.78% overall [PMID 26833165]

Medication	Dosage Form	Dosing	Other
Amoxicillin (Amoxil®)	Capsule 250 mg 500 mg ($) Tablet 500 mg 875 mg ($) Tablet, chewable 125 mg 250 mg ($) Tablet, extended-release (Moxatag®) 775 mg ($$$) Suspension 125 mg/5 ml 200 mg/5 ml 250 mg/5 ml 400 mg/5 ml ($)	Pediatric Endocarditis prophylaxis - 50 mg/kg (max 2000 mg) 30 - 60 minutes before procedure (AHA) H. pylori - Amoxicillin - 50 mg/kg/day (max 2000 mg/day) given in 2 divided doses + Proton Pump Inhibitor (PPI) + Clarithromycin - 20 mg/kg/day (max 1000 mg/day) given in 2 divided doses; OR Metronidazole - 20 mg/kg/day (max 1000 mg/day) given in 2 divided doses (CTE) DURATION: 10 - 14 days H. pylori, sequential therapy - see H. pylori treatment Otitis media - 80 - 90 mg/kg/day given in 2 divided doses for 5 - 10 days (AAP) Pneumonia, community-acquired - 90 mg/kg/day (max 4000 mg/day) given in 2 divided doses for 7 - 10 days (IDSA) Sinusitis Standard therapy - 45 mg/kg/day given in 2 divided doses for a minimum of 10 days (AAP) High-dose therapy - 80 to 90 mg/kg/day (max 4000 mg/day) given in 2 divided doses for a minimum of 10 days (AAP) Strep throat - 50 mg/kg/day (max 1000 mg/day) given once daily or in 2 divided doses for 10 days (IDSA) Adults Endocarditis prophylaxis - 2000 mg 30 - 60 minutes before procedure (AHA) H. pylori - Amoxicillin - 1000 mg twice a day + Clarithromycin - 500 mg twice a day + Proton Pump Inhibitor (PPI) (ACG) DURATION: 10 - 14 days H. pylori, sequential therapy - see H. pylori treatment Pneumonia, community-acquired - Amoxicillin 1000 mg three times a day for 7 - 14 days + Macrolide (IDSA) Strep throat - 1000 mg once daily or 500 mg twice a day for 10 days (IDSA) Syphilis (primary, secondary, early latent, latent) - Amoxicillin 1000 mg three times a day + probenecid 250 mg three times a day for 14 - 16 days (based on PMID 25829004)	May take without regard to food Kidney disease CrCl 10 - 30 ml/min: 250 - 500 mg every 12 hours CrCl < 10 ml/min: 250 - 500 mg every 24 hours
Amoxicillin- clavulanate (Augmentin®)	Tablet (amoxil : clav) 250 mg : 125 mg ($$) 500 mg : 125 mg ($) 875 mg : 125 mg ($) Tablet, chewable (amoxil : clav) 7:1 ratio 200 mg : 28.5 mg 400 mg : 57 mg ($) Tablet, extended-release (Augmentin XR®) 1000 mg : 62.5 mg ($$) Suspension (amoxil:clav) 4:1 ratio 125 mg : 31.25 mg/5 ml 250 mg : 62.5 mg/5 ml ($) 7:1 ratio 200 mg : 28.5 mg/5 ml 400 mg : 57 mg/5 ml ($) 14:1 ratio (Augmentin ES®) 600 mg : 42.9 mg/5 ml ($)	Pediatric Impetigo - 25 mg/kg/day (max 1750 mg/day) of the amoxicillin component given in 2 divided doses for 7 days (IDSA) Otitis media - 90 mg/kg/day of amoxicillin, with 6.4 mg/kg/day of clavulanate [amoxicillin to clavulanate ratio, 14:1] (max 4000 mg/day) in 2 divided doses for 5 - 10 days (AAP) Pneumonia, community-acquired - 90 mg/kg/day (max 4000 mg/day) given in 2 divided doses for 7 - 10 days (IDSA) Sinusitis - 80 – 90 mg/kg/day of the amoxicillin component with 6.4 mg/kg/day of clavulanate [amoxicillin to clavulanate ratio, 14:1] in 2 divided doses (max 4000 mg/day) for a minimum of 10 days (AAP) Urinary tract infection - 20 - 40 mg/kg/day given in 3 divided doses for 7 - 14 days (CTE) Adults Bite, animal - 875/125 mg twice a day (IDSA) Bite, human - 875/125 mg twice a day (IDSA) Diabetic foot ulcer (mild, non-MRSA) - 875/125 mg twice a day for 7 - 14 days (IDSA) Diverticulitis - 875/125 mg twice a day for 7 - 14 days (CTE) Impetigo - 875/125 mg twice a day for 7 days (IDSA) Pneumonia, community-acquired - Amoxicillin-clavulanate 2000 mg two times a day for 7 - 14 days + Macrolide (IDSA) Sinusitis Standard therapy - 875/125 mg twice a day for 5 - 7 days (IDSA) High-dose therapy - 2000 mg twice a day for 5 - 7 days (IDSA) Urinary tract infection - 875/125 mg twice a day for 3 - 7 days (IDSA)	May take without regard to meals, although taking with food may help reduce gastrointestinal upset Amoxicillin-clavulanate preparations with a 14:1 ratio of amoxicillin-clavulanate may be less likely to cause diarrhea than preparations with a lower ratio Kidney disease Standard tablet and suspension CrCl < 30 ml/min: do not give 875 mg dose CrCl 10 - 30 ml/min: 250 - 500 mg every 12 hours CrCl < 10 ml/min: 250 - 500 mg every 24 hours
Dicloxacillin	Capsule 250 mg 500 mg ($)	Pediatric Cellulitis (non-MRSA) - 25 - 50 mg/kg/day (max 2000 mg/day) given in 4 divided doses for 5 - 10 days (IDSA) Adults Cellulitis (non-MRSA) - 500 mg four times a day for 5 - 10 days (IDSA) Diabetic foot ulcer (mild, non-MRSA) - 500 mg four times a day for 7 - 14 days (IDSA) Impetigo - 250 mg four times a day for 7 days (IDSA)	Should be taken on an empty stomach at least 1 hour before and 2 hours after a meal Kidney disease - dose reduction recommended. Manufacturer makes no specific recommendation.
Penicillin G benzathine (Bicillin L-A®)	Disposable syringe 1 ml - 600,000 units ($$) 2 ml - 1,200,000 units ($$$) 4 ml - 2,400,000 units ($$$$)	Pediatric Strep throat < 27 kg - 600,000 units IM single dose (IDSA) ≥ 27 kg - 1,200,000 units IM single dose (IDSA) Impetigo ≤ 6 kg - 225 mg (300,000 units) IM given as a one time dose 6.1 - 10 kg - 337.5 mg (450,000 units) IM given as a one time dose 10.1 - 15 kg - 450 mg (600,000 units) IM given as a one time dose 15.1 - 20 kg - 675 mg (900,000 units) IM given as a one time dose > 20 kg - 900 mg (1,200,000 units) IM given as a one time dose [Dosing based on PMID 25172376] Adults Strep throat - 1,200,000 units IM single dose Syphilis Primary and secondary - 2.4 million units IM single dose (CDC) Early latent - 2.4 million units IM single dose (CDC) Latent - 2.4 million units IM once a week for a total of 3 doses (CDC) Tertiary - 2.4 million units IM once a week for a total of 3 doses (CDC)	For IM use only Kidney disease - clearance is decreased. Manufacturer makes no specific recommendation. Milligram-unit conversion 225 mg = 300,000 units 337.5 mg = 450,000 units 450 mg = 600,000 units 675 mg = 900,000 units 900 mg = 1,200,000 units
Penicillin (Pen VK®)	Tablet 250 mg 500 mg ($) Solution 125 mg/5 ml 250 mg/5 ml ($)	Pediatric Strep throat - 250 mg two to three times a day for 10 days (IDSA) Adults Cellulitis (Streptococcal infections) - 250 - 500 mg four times a day for 5 - 10 days (IDSA) Strep throat - 250 mg four times a day or 500 mg twice a day for 10 days (IDSA)	May take without regard to meals Kidney disease - drug clearance is decreased. Manufacturer makes no specific dosage recommendation.

Medication	Dosage Form	Dosing	Other
Ciprofloxacin (Cipro®)	Suspension 250 mg/5 ml ($$-$$$) 500 mg/5 ml ($$-$$$) Tablet 100 mg 250 mg 500 mg 750 mg ($) Tablet, extended-release 500 mg 1000 mg ($-$$) Ophthalmic See Conjunctivitis Otic See Otitis externa	Pediatric (≥ 1 year old) Urinary tract infection - 10 - 20 mg/kg/dose (maximum 750 mg/dose) every 12 hours for 7 - 14 days (PI) Adults Bite, human - Ciprofloxacin - 500 - 750 mg twice a day + metronidazole250 - 500 mg three times a day (IDSA) Diabetic foot ulcer (moderate) - Ciprofloxacin 500 mg twice a day +clindamycin 300 - 450 mg four times a day for 7 - 14 days (IDSA) Diverticulitis - Ciprofloxacin 500 mg twice a day + metronidazole 500 mg three to four times a day for 7 - 14 days (CTE) E Coli, enterotoxigenic - 500 mg twice a day or 750 mg once daily for 1 - 3 days (CTE/IDSA) Prostatitis, acute - 500 mg twice a day for 2 - 4 weeks (CTE) Prostatitis, chronic - 500 mg twice a day for 4 - 6 weeks (CTE, PI) Pyelonephritis Standard-release - 500 mg twice a day for 7 days (IDSA) Extended-release - 1000 mg once daily for 7 days (IDSA) NOTE: If community resistance to fluoroquinolones is > 10%, then also give Ceftriaxone 1000 mg IM one time dose (IDSA) Salmonella, nontyphoidal - 500 mg twice a day for 5 - 10 days (CTE/IDSA) Shigella - 750 mg once daily or 500 mg twice a day for 3 days (CTE/IDSA) Sinusitis - 500 mg twice a day for 10 days (PI) Urinary tract infection Standard-release - 250 mg twice a day for 3 days (IDSA, PI) Extended-release - 500 mg once daily for 3 days (IDSA, PI) Vibrio vulnificus - 750 mg once daily for 3 days (CTE)	May take without regard to food Do not take with tizanidine (Zanaflex®) Take 2 hours before or 6 hours after magnesium or aluminum antacids Ciprofloxacin is a Strong CYP1A2 inhibitor May cause photosensitivity. Limit sun exposure, use sunscreen. Liver disease - in studies involving patients with chronic cirrhosis, no significant changes in ciprofloxacin pharmacokinetics were observed. The effects of acute hepatic insufficiency on ciprofloxacin are unknown. Kidney disease Standard-release CrCl > 50 ml/min: no dose adjustment necessary CrCl 30 - 50 ml/min: 250 - 500 mg every 12 hours CrCl 5 - 29 ml/min: 250 - 500 mg every 18 hours Extended-release CrCl ≤ 30 ml/min: - 500 mg once daily
Gemifloxacin (Factive®)	Tablet 320 mg ($$$$)	Adults Gonorrhea - gemifloxacin 320 mg single dose + azithromycin 2000 mg single dose (based on PMID 25031289) Pneumonia, community-acquired - 320 mg once daily for 5 - 7 days (IDSA, PI)	May take without regard to food Antacids, sucralfate, metal cations (e.g. iron), and multivitamins may reduce gemifloxacin absorption. Gemifloxacin should be taken 3 hours before or 2 hours after these medications. Liver disease - no dose adjustment necessary Kidney disease CrCl ≤ 40 ml/min: 160 mg every 24 hours
Levofloxacin (Levaquin®)	Tablet 250 mg 500 mg 750 mg ($) Solution 25 mg/ml ($$) Ophthalmic See Conjunctivitis	Pediatric Pneumonia, community-acquired 6 months - 5 years old - 16 - 20 mg/kg/day given in 2 divided doses for 7 - 10 days (IDSA) 5 - 16 years old - 8 - 10 mg/kg/day (max 750 mg/day) given once daily for 7 - 10 days (IDSA) Sinusitis - 16 mg/kg/day (max 500 mg/day) given in 2 divided doses for a minimum of 10 days (AAP) Adults Bite, animal - Levofloxacin 750 mg once daily + clindamycin 300 mg three times a day; OR metronidazole 250 - 500 mg three times a day (IDSA) Bite, human - Levofloxacin 750 mg once daily + metronidazole 250 - 500 mg three times a day (IDSA) Chlamydia - 500 mg once daily for 7 days (CDC) Diabetic foot ulcer (mild, non-MRSA) - 750 mg once daily for 7 - 14 days (IDSA) Diabetic foot ulcer (moderate) - Levofloxacin 750 mg once daily +clindamycin 300 - 450 mg four times a day for 7 - 14 days (IDSA) Diverticulitis - Levofloxacin 750 mg once daily + metronidazole 500 mg three to four times a day for 7 - 14 days (CTE) Epididymitis (likely caused by urinary tract pathogens) - 500 mg once daily for 10 days (CDC) H. pylori - Levofloxacin 500 mg once daily + amoxicillin 1000 mg twice a day + PPI for 10 days (ACG) Pneumonia, community-acquireda - 500 mg once daily for 7 - 14 days (PI) Pneumonia, community-acquiredb - 750 mg once daily for 5 days (IDSA, PI) Pneumonia, nosocomial - 750 mg once daily for 7 - 14 days (PI) Prostatitis, acute - 500 mg - 750 mg once daily for 2 - 4 weeks (CTE) Prostatitis, chronic - 500 mg once daily for 4 - 6 weeks (CTE, PI) Pyelonephritis - 750 mg once daily for 5 days; if community resistance to fluoroquinolones is > 10%, then also give Ceftriaxone 1000 mg IM one time dose (IDSA) Salmonella, nontyphoidal - 500 mg once daily for 5 - 10 days (CTE/IDSA) Sinusitis - 750 mg once daily for 5 days OR 500 mg once daily for 10 - 14 days (IDSA, PI) Skin infections, complicated - 750 mg once daily for 7 - 14 days (PI) Skin infections, uncomplicated - 500 mg once daily for 7 - 10 days (PI) Urinary tract infection - 250 mg once daily for 3 days (IDSA, PI) Urinary tract infection, complicatedc - 750 mg once daily for 5 days (PI) Urinary tract infection, complicatedd - 250 mg once daily for 10 days (PI) aDue to methicillin-susceptible Staphylococcus aureus, Streptococcus pneumoniae (including multidrug-resistant isolates [MDRSP]), Haemophilus influenzae, Haemophilus parainfluenzae, Klebsiella pneumoniae, Moraxella catarrhalis, Chlamydophila pneumoniae, Legionella pneumophila, or Mycoplasma pneumoniae bDue to Streptococcus pneumoniae (excluding multi-drug-resistant isolates [MDRSP]), Haemophilus influenzae, Haemophilus parainfluenzae, Mycoplasma pneumoniae, or Chlamydophila pneumoniae c due to Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis and pyelonephritis due to E. coli, including cases with concurrent bacteremia d Enterococcus faecalis, Enterococcus cloacae, Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Pseudomonas aeruginosa; and for pyelonephritis due to E. coli	May take without regard to food Antacids, sucralfate, metal cations (e.g. iron), and multivitamins may reduce levofloxacin absorption. Do not take within 2 hours of each other. Quinolones have not been considered first-line agents in children because of the possible risk of adverse effects on developing cartilage. In studies, these effects appear to be uncommon. [1] May cause photosensitivity. Limit sun exposure, use sunscreen. Liver disease - no dose adjustment necessary Kidney disease CrCl ≤ 49 ml/min: dose adjustment recommended; see Levaquin® PIfor more.
Moxifloxacin (Avelox®)	Tablet 400 mg ($$-$$$) Ophthalmic See Conjunctivitis	Adults Bite, animal - 400 mg once daily (IDSA) Bite, human - 400 mg once daily (IDSA) Diabetic foot ulcer (moderate, non-MRSA) - 400 mg once daily for 7 - 14 days (IDSA) Diverticulitis - 400 mg once daily for 7 - 14 days (CTE) Mycoplasma genitalium - 400 mg once daily for 7, 10, or 14 days (CDC) Pneumonia, community-acquired - 400 mg once daily for 7 - 14 days (IDSA, PI) Sinusitis - 400 mg once daily for 10 days (IDSA, PI) Skin infections, uncomplicated - 400 mg once daily for 7 days (PI) Skin infections, complicated - 400 mg once daily for 7 - 21 days (PI)	May take without regard to food Antacids, sucralfate, metal cations (e.g. iron), and multivitamins may reduce moxifloxacin absorption. Moxifloxacin should be taken 4 hours before or 8 hours after these medications. Liver disease - no dose adjustment necessary Kidney disease - no dose adjustment necessary
Ofloxacin	Tablet 200 mg 300 mg 400 mg ($$) Ophthalmic See Conjunctivitis Otic See Otitis Externa	Adults Chlamydia - 300 mg twice a day for 7 days (CDC) E. coli, enterotoxigenic - 300 mg twice a day for 3 days (IDSA) Epididymitis (likely caused by urinary tract pathogens) - 300 mg twice a day for 10 days (CDC) Pelvic inflammatory disease - 400 mg twice a day for 10 - 14 days (PI) Pneumonia, community-acquired - 400 mg twice a day for 10 days (PI) Prostatitis due to E. coli - 300 mg twice a day for 6 weeks (PI) Salmonella, nontyphoidal - 300 mg twice a day for 5 -7 days (IDSA) Shigella - 300 mg twice a day for 3 days (IDSA) Skin infections, uncomplicated - 400 mg twice a day for 10 days (PI) Urinary tract infection due to E. coli or K. pneumoniae - 200 mg twice a day for 3 days (IDSA, PI) Urinary tract infection due to other pathogens - 200 mg twice a day for 7 days (PI) Urinary tract infections, complicated - 200 mg twice a day for 10 days (PI)	May take without regard to food Antacids, sucralfate, metal cations (e.g. iron), and multivitamins may reduce ofloxacin absorption. Do not take within 2 hours of each other. May cause photosensitivity. Limit sun exposure, use sunscreen. Liver disease Severe (Child-Pugh C): do not exceed 400 mg/day Kidney disease CrCl 20 - 50 ml/min: usual dose every 24 hours CrCl < 20 ml/min: half the usual dose every 24 hours

Medication	Dosage Form	Dosing	Other
Sulfamethoxazole- trimethoprim (Septra®) (Bactrim®)	Tablet (sulfa/tmp) 800/160 mg (double strength) 400/80 mg (single strength) ($) Suspension (sulfa/tmp) 200 mg/40 mg/5 ml ($)	Pediatric (≥ 2 months old) NOTE: All pediatric dosing based on trimethoprim component Cellulitis (MRSA coverage) - 8 – 12 mg/kg/day given in 2 divided doses for 5 - 10 days (IDSA) Cyclospora - 5 mg/kg/day (max 320 mg/day) given in 2 divided doses for 3 days (CTE) Impetigo Once daily - 8 mg/kg/day (max 320 mg/day) given once daily for 5 days Twice daily - 8 mg/kg/day (max 320 mg/day) given in two divided doses for 3 days (Dosing based on PMID 25172376) Salmonella, nontyphoidal - 10 mg/kg/day (max 320 mg/day) given in 2 divided doses for 5 - 7 days (IDSA) Shigella - 10 mg/kg/day (max 320 mg/day) given in 2 divided doses for 3 days (IDSA) Urinary tract infection - 6 - 12 mg/kg/day (max 320 mg/day) given in 2 divided doses for 7 - 14 days (CTE) Urinary tract infection, prophylaxis - 3 mg/kg/day (max 40 mg/day) given once daily (CTE) Adolescents and adults Acne - 800/160 twice a day (AAP) Bite, animal - Sulfamethoxazole-trimethoprim 800/160 twice a day + clindamycin 300 mg three times a day; OR metronidazole 250 - 500 mg three times a day (IDSA) Cellulitis (MRSA coverage) - one to two 800/160 tablet(s) twice a day for 5 - 10 days (IDSA) Cyclospora - 800/160 twice a day for 7 days (IDSA) Diabetic foot ulcer (mild, MRSA coverage) - one to two 800/160 tablet(s) twice a day for 7 - 14 days (IDSA) Diverticulitis - Sulfamethoxazole-trimethoprim 800/160 twice a day +metronidazole 500 mg three to four times a day for 7 - 14 days (CTE) E.Coli, enterotoxigenic - 800/160 twice a day for 3 days (IDSA) Prostatitis, acute - 800/160 twice a day for 2 - 4 weeks (CTE) Prostatitis, chronic - 800/160 twice a day for 4 - 6 weeks (CTE) Pyelonephritis - 800/160 twice a day for 14 days; If this regimen is used empirically, then also give Ceftriaxone 1000 mg IM one time dose (IDSA) Salmonella, nontyphoidal - 800/160 twice a day for 5 -7 days (IDSA) Shigella - 800/160 twice a day for 3 days (IDSA) Urinary tract infection - 800/160 twice a day for 3 days (as long as local resistance rates do not exceed 20%) (IDSA) Urinary tract infection, prophylaxis Postcoital - 200/40 one time postcoital (CTE) Continuous - 200/40 once daily OR 200/40 three times a week (CTE)	May be taken without regard to food May cause photosensitivity. Limit sun exposure, use sunscreen. Trimethoprim may raise potassium levels in susceptible patients Trimethoprim is a CYP2C8 inhibitor Trimethoprim is an OCT2 inhibitor and substrate Sulfamethoxazole is a Weak CYP2C9 inhibitor Liver disease - do not use in patients with significant liver disease Kidney disease CrCL > 30 ml/min: no dose adjustment necessary CrCl 15 - 30 ml/min: use half the usual dose CrCl < 15 ml/min: do not use

Medication	Dosage Form	Dosing	Other
Doxycycline Monohydrate and Hyclate (Acticlate®) (Vibramycin®) (Doryx®) (Oracea®)	Monohydrate Capsule 50 mg, 100 mg ($) 75 mg, 150 mg ($$$$) Capsule (Oracea®) 40 mg ($$$$) Contains 30 mg immediate release and 10 mg delayed release Tablet 50 mg, 75 mg, 100 mg ($) 150 mg ($$$-$$$$) Suspension 25 mg/5 ml ($-$$) Hyclate Capsule 50 mg 100 mg ($-$$) Capsule - delayed release 75 mg 100 mg ($$-$$$) Tablet 20 mg ($) 100 mg ($-$$) Tablet - delayed release (Doryx®) 50 mg 75 mg 100 mg 150 mg 200 mg ($$-$$$$) Tablet (Acticlate®) 75 mg 150 mg ($$$$)	Pediatric (≥ 8 years old) Pneumonia, community-acquired, atypical - 2 - 4 mg/kg/day given in 2 divided doses for 7 - 10 days (IDSA) Adolescents and adults Acne - 50 - 150 mg once daily or 50 - 100 mg twice a day (AAP) Bite, animal - 100 mg twice a day (IDSA) Bite, human - 100 mg twice a day (IDSA) Cellulitis (MRSA coverage) - 100 mg twice a day 5 - 10 days (IDSA) Chlamydia - 100 mg twice a day for 7 days (CDC) Diabetic foot ulcer (mild, MRSA coverage) - 100 mg twice a day for 7 - 14 days (IDSA) Epididymitis (likely caused by chlamydia or gonorrhea) Doxycycline - 100 mg twice a day for 10 days + Ceftriaxone 250 mg IM single dose (CDC) Gonorrhea Doxycycline - 100 mg twice a day for 7 days + Ceftriaxone 250 mg IM single dose (CDC) Doxycycline - 100 mg twice a day for 7 days + Cefixime 400 mg single dose (CDC) Malaria prophylaxis - 100 mg once daily starting 1 - 2 days before travel. Continue while in endemic region and for 4 weeks after leaving region. [CDC] Pneumonia, community-acquired - 100 mg twice a day for 7 - 14 days (IDSA, CTE) [3,4] Prostatitis, chronic - 100 mg twice a day for 4 - 6 weeks (CTE) Rosacea (Oracea®) - 40 mg once daily in the morning on an empty stomach (preferably ≥ 1 hour before or 2 hours after a meal) Sinusitis - 100 mg twice a day for 7 days (IDSA, PI) Syphilis (primary and secondary, pen-allergic) - 100 mg twice a day for 14 days (CDC) Syphilis (latent, pen-allergic) - 100 mg twice a day for 28 days (CDC)	May be taken without regard to food (except Oracea®) Take with full glass of water to reduce risk of esophageal irritation Dairy products do not affect doxycycline absorption Concomitant use of tetracyclines and isotretinoin has been associated with pseudotumor cerebri. Concurrent use should be avoided. May cause photosensitivity. Limit sun exposure, use sunscreen. Antacids may decrease bioavailability of doxycycline. Do not take within 4 hours of each other. Doxycycline should not be used in children < 8 years old because of possible tooth discoloration Kidney disease - no dose adjustment necessary
Minocycline (Minocin®) (Dynacin®) (Solodyn®)	Capsule 50 mg 75 mg 100 mg ($) Tablet 50 mg 75 mg 100 mg ($$$-$$$$) Tablet, extended-release (Solodyn®) 45 mg 65 mg 80 mg 90 mg 105 mg 115 mg 135 mg ($$$-$$$$)	Adolescents and adults - standard-release Acne - 50 - 100 mg once daily or 50 - 100 mg twice a day (AAP) Cellulitis (MRSA coverage) - 100 mg twice a day 5 - 10 days (IDSA) Adolescents and adults - extended-release tablets Acne - 1 mg/kg/day (max 135 mg/day) given once daily (PI)	May be taken without regard to food Dairy products do not affect minocycline absorption Take with full glass of water to reduce risk of esophageal irritation Antacids may decrease bioavailability of minocycline. Do not take within 4 hours of each other. May cause photosensitivity. Limit sun exposure, use sunscreen. Concomitant use of tetracyclines and isotretinoin has been associated with pseudotumor cerebri. Concurrent use should be avoided. May cause hyperpigmentation around scars, shins, and mucous membranes with prolonged use Minocycline should not be used in children < 8 years old because of possible tooth discoloration Liver disease - use caution. Manufacturer makes no specific recommendation. Kidney disease - has not been studied. Manufacturer makes no specific recommendation.
Tetracycline (Achromycin V®)	Capsule 250 mg ($) 500 mg ($$$-$$$$)	Adolescents and adults Acne - 500 mg twice a day (AAP) Syphilis (primary and secondary, pen-allergic) - 500 mg four times a day for 14 days (CDC) Syphilis (latent, pen-allergic) - 500 mg four times a day for 28 days (CDC)	Take at least 1 hour before food or two hours after Dairy products taken at the same time as tetracycline may decrease absorption Take with full glass of water to reduce risk of esophageal irritation Antacids may decrease bioavailability of tetracycline. Do not take within 4 hours of each other. May cause photosensitivity. Limit sun exposure, use sunscreen. Concomitant use of tetracyclines and isotretinoin has been associated with pseudotumor cerebri. Concurrent use should be avoided. Tetracycline should not be used in children < 8 years old because of possible tooth discoloration Kidney disease - dose reduction recommended. Manufacturer makes no specific recommendation.

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