INSULIN CHART

RAPID-ACTING INSULINS

Afrezza® (inhaled insulin)Apidra® (insulin glulisine)Humalog® (insulin lispro)Novolog® (insulin aspart)

 

SHORT-ACTING INSULINS

Humulin® R (regular)Novolin® R (regular)

 

INTERMEDIATE-ACTING INSULINS

Humulin® N (NPH)Novolin® N (NPH)

 

LONG-ACTING INSULINS

Basaglar® (insulin glargine)Lantus® (insulin glargine)Toujeo® (insulin glargine)Levemir® (insulin detemir)Tresiba® (insulin degludec)

COMBINATION PRODUCTS

Humalog® Mix 75/25, 50/50Humulin® 70/30Novolin® 70/30Novolog® Mix 70/30Ryzodeg® 70/30

 

OTHER RELATED PAGES

Insulin dosingType one diabetesType two diabetesDiabetes managementInsulin review

 

Insulin pricing

Drug	Dosage form	Pharmacokinetics	Mixing/Dosing/Other	Storage
Afrezza® (inhaled insulin)	Cartridge 4 unit cartridge of inhalation powder 8 unit cartridge of inhalation powder Packaged as follows: 60 four unit cartridges 90 four unit cartridges 90 eight unit cartridges 60 four unit and 30 eight unit 30 four unit and 60 eight unit 90 four unit and 90 eight unit	Onset of action 10 - 30 minutes Duration of action ∼ 2.6 hours Peak effect ∼ 53 minutes	MIXING Does not apply DOSING Insulin-naïve patients 4 units with the start of each meal Patients on injectable insulin See Conversion table OTHER See Inhaled insulin for a complete review of Afrezza®	PACKAGING Afrezza® comes in a sealed foil package with 2 blister cards inside Each blister card has 5 rows of 3 cartridges 3 cartridges are under one blister Before use, cartridge and inhaler should be at room temperature for 10 minutes Inhaler should be thrown away after 15 days REFRIGERATED Sealed foil package is good until expiration date ROOM TEMPERATURE Sealed foil package - use within 10 days Sealed blister cards + strips - use within 10 days Opened blister - use within 3 days

Drug	Dosage form	Pharmacokinetics	Mixing/Dosing/Other	Storage
Apidra® (insulin glulisine)	Vial (100 units/ml) 10 ml vial SoloStar® (100 units/ml) 3 ml pen Comes in package of 5 Needles SoloStar® is compatible with all BD® pen needles	Onset of action 10 - 30 minutes Duration of action 3 - 5 hours Peak effect 1/2 - 2 hours	MIXING Mix with NPH only Draw Apidra® first, then NPH Inject immediately DOSING Dosage will vary by patient Apidra® is a premeal (also called prandial) insulin Apidra® should be given within 15 minutes before a meal or within 20 minutes after starting a meal See insulin dosing for more OTHER Apidra® should be clear and colorless Apidra® is compatible with some insulin pumps	UNPUNCTURED, REFRIGERATED (Vials and Pens) Good until expiration date on product UNPUNCTURED, ROOM TEMP (Vials and Pens) Good for 28 days PUNCTURED (Vials) Refrigerate or room temperature Good for 28 days PUNCTURED (Pens) Do not refrigerate Keep at room temperature Good for 28 days

Drug	Dosage form	Pharmacokinetics	Mixing/Dosing/Other	Storage
Humalog® (insulin lispro)	Vial (100 units/ml) 10 ml vial KwikPen® (100 units/ml) 3 ml pen Comes in package of 5 pens KwikPen® (200 units/ml) 3 ml pen Comes in package of 5 pens Cartridge (100 units/ml) 3 ml cartridge Comes in package of 5 cartridges For use in HumaPen® Luxura HD and HumaPen® Memoir (see Other for details) Needles KwikPen® is compatible with all BD® pen needles	Onset of action 10 - 30 minutes Duration of action 3 - 5 hours Peak effect 1/2 - 2 hours	MIXING Mix with NPH only Draw Humalog® first, then NPH Inject immediately DOSING Dosage will vary by patient Humalog® is a premeal (also called prandial) insulin Humalog® should be given within 15 minutes before a meal or immediately after a meal See insulin dosing for more OTHER Humalog® should be clear and colorless Humalog® is compatible with some insulin pumps HumaPen® Luxura HD is a reusable pen that allows dosing in 0.5 unit increments HumaPen® Memoir records the time, date, and dose of the last 16 injections	UNPUNCTURED, REFRIGERATED (Vials, Pens, Cartridges) Good until expiration date on product UNPUNCTURED, ROOM TEMP (Vials, Pens, Cartridges) Good for 28 days PUNCTURED (Vials) Refrigerate or room temperature Good for 28 days PUNCTURED (Pens, Cartridges) Do not refrigerate Keep at room temperature Good for 28 days

Drug	Dosage form	Pharmacokinetics	Mixing/Dosing/Other	Storage
Novolog® (insulin aspart)	Vial (100 units/ml) 10 ml vial FlexPen® (100 units/ml) 3 ml pen Comes in package of 5 FlexTouch® (100 units/ml) 3 ml pen Comes in package of 5 FlexTouch® pen button maintains the same extension at all doses Cartridge (100 units/ml) 3 ml cartridge for use in NovoPen® reusable pens Needles Uses NovoFine® and NovoTwist® pen needles BD® Ultra-fine needles are compatible with FlexPen®	Onset of action 10 - 30 minutes Duration of action 3 - 5 hours Peak effect 1/2 - 2 hours	MIXING Mix with NPH only Draw Novolog® first, then NPH Inject immediately DOSING Dosage will vary by patient Novolog® is a premeal (also called prandial) insulin Novolog® should be injected immediately (within 5-10 minutes) before a meal See insulin dosing for more OTHER Novolog® should be clear and colorless Novolog® is compatible with some insulin pumps	UNPUNCTURED, REFRIGERATED (Vials, Pens, Cartridges) Good until expiration date on product UNPUNCTURED, ROOM TEMP (Vials, Pens, Cartridges) Good for 28 days PUNCTURED (Vials) Refrigerate or room temperature Good for 28 days PUNCTURED (Pens, Cartridges) Do not refrigerate Keep at room temperature Good for 28 days

Drug	Dosage form	Pharmacokinetics	Mixing/Dosing/Other	Storage
Humulin® R (regular)	Humulin® R U-100 Contains 100 units/ml 10 ml vial Humulin® R U-500Contains 500 units/ml 20 ml vial U-500 syringe must be prescribed with vial Humulin® R U-500 KwikPen®Contains 500 units/ml 3 ml pen Comes in carton of 2 or 5 pens Syringes (U-500) Humulin® R U-500 insulin syringe for use with U-500 vial Syringe must be prescribed with U-500 vial Syringe is only for use with U-500 vial	Onset of action 30 - 60 minutes Duration of action 6 - 8 hours Peak effect 2 - 3 hours	MIXING Mix with NPH only Draw Humulin® R first, then NPH Inject immediately DOSING Dosage will vary by patient Humulin® R is a premeal (also called prandial) insulin Humulin® R should be followed by a meal within approximately 30 minutes of administration See insulin dosing for more OTHER Humulin® R should be clear and colorless Humulin® R U-500 should only be prescribed to patients who require > 200 units of insulin per day	UNPUNCTURED, REFRIGERATED (Vials) Good until expiration date on product UNPUNCTURED, ROOM TEMP (Vials) Good for 40 days PUNCTURED (Vials) Refrigerate or room temperature Good for 40 days UNPUNCTURED, REFRIGERATED (Pens) Good until expiration date on product UNPUNCTURED, ROOM TEMP (Pens) Good for 28 days PUNCTURED (Pens) Do not refrigerate Good for 28 days

Drug	Dosage form	Pharmacokinetics	Mixing/Dosing/Other	Storage
Novolin® R (regular)	Vial (100 units/ml) 10 ml vial	Onset of action 30 - 60 minutes Duration of action 6 - 8 hours Peak effect 2 - 3 hours	MIXING Mix with NPH only Draw Novolin® R first, then NPH Inject immediately DOSING Dosage will vary by patient Novolin® R is a premeal (also called prandial) insulin Novolin® R should generally be injected approximately 30 minutes prior to the start of a meal See insulin dosing for more OTHER Humulin® R should be clear and colorless	UNPUNCTURED, REFRIGERATED (Vials) Good until expiration date on product UNPUNCTURED, ROOM TEMP (Vials) Good for 28 days PUNCTURED (Vials) Refrigerate or room temperature Good for 28 days

Drug	Dosage form	Pharmacokinetics	Mixing/Dosing/Other	Storage
Humulin® N (NPH)	Vial (100 units/ml) 10 ml vial KwikPen® (100 units/ml) 3 ml pen Comes in package of 5 Needles Compatible with BD® pen needles	Onset of action 2 - 4 hours Duration of action up to 20 hours Peak effect 4 - 10 hours	MIXING Humulin® N can be mixed with Regular, Apidra®, Humalog®, and Novolog® Draw Humulin® N after other insulin Inject immediately DOSING Dosage will vary by patient Humulin® N is a basal insulin See insulin dosing for more OTHER Humulin® N should be mixed before use (see instructions with product) Humulin® N should appear uniformly cloudy with no particulate matter after mixing Information on converting between NPH and other insulins - Click here	UNPUNCTURED, REFRIGERATED (Vials, Pens) Good until expiration date on product UNPUNCTURED, ROOM TEMP (Vials) Good for 31 days UNPUNCTURED, ROOM TEMP (Pens) Good for 14 days PUNCTURED (Vials) Refrigerated or room temp Good for 31 days PUNCTURED (Pens) Do not refrigerate Keep at room temperature Good for 14 days

Drug	Dosage form	Pharmacokinetics	Mixing/Dosing/Other	Storage
Novolin® N (NPH)	Vial (100 units/ml) 10 ml vial	Onset of action 2 - 4 hours Duration of action up to 20 hours Peak effect 4 - 10 hours	MIXING Novolin® N can be mixed with Regular, Apidra®, Humalog®, and Novolog® Draw Novolin® N after other insulin Inject immediately DOSING Dosage will vary by patient Novolin® N is a basal insulin See insulin dosing for more OTHER Novolin® N should be mixed before use (see instructions with product) Novolin® N should appear uniformly cloudy with no particulate matter after mixing Information on converting between NPH and other insulins - Click here	UNPUNCTURED, REFRIGERATED (Vials) Good until expiration date on product UNPUNCTURED, ROOM TEMP (Vials) Vials are good for 42 days PUNCTURED (Vials) Refrigerated or room temp Good for 42 days

Drug	Dosage form	Pharmacokinetics	Mixing/Dosing/Other	Storage
Basaglar® (insulin glargine)	Kwikpen® (100 units/ml) 3 ml pen Comes in package of 5 pens Needles Compatible with BD® pen needles	Onset of action 1 - 3 hours Duration of action 24+ hours Peak effect No peak	MIXING DO NOT MIX with other insulins DOSING Dosage will vary by patient The recommended starting dose of Basaglar® in patients with type 2 diabetes who are not currently treated with insulin is 10 units (or 0.2 units/kg)once daily Basaglar® may be administered at any time during the day Basaglar® should be administered at the same time every day Basaglar® is a basal insulin See insulin dosing for more OTHER Basaglar® should be clear and colorless Information on converting between Basaglar® and other insulins - Click here	UNPUNCTURED, REFRIGERATED (Pens) Good until expiration date on product UNPUNCTURED, ROOM TEMP (Pens) Pens are good for 28 days PUNCTURED (Pens) Do not refrigerate Keep at room temperature Good for 28 days

Drug	Dosage form	Pharmacokinetics	Mixing/Dosing/Other	Storage
Lantus® (insulin glargine)	Vial (100 units/ml) 10 ml vial SoloStar® (100 units/ml) 3 ml pen Comes in package of 5 pens Needles Compatible with BD® pen needles	Onset of action 1 - 3 hours Duration of action 24+ hours Peak effect No peak	MIXING DO NOT MIX with other insulins DOSING Dosage will vary by patient The recommended starting dose of Lantus® in patients with type 2 diabetes who are not currently treated with insulin is 10 units (or 0.2 units/kg) once daily Lantus® may be administered at any time during the day Lantus® should be administered at the same time every day Lantus® is a basal insulin See insulin dosing for more OTHER Lantus® should be clear and colorless Information on converting between Lantus® and other insulins - Click here	UNPUNCTURED, REFRIGERATED (Vials, Pens) Good until expiration date on product UNPUNCTURED, ROOM TEMP (Vials) Good for 28 days UNPUNCTURED, ROOM TEMP (Pens) Good for 28 days PUNCTURED (Vials) Refrigerated or room temp Good for 28 days PUNCTURED (Pens) Do not refrigerate Keep at room temperature Good for 28 days

Drug	Dosage form	Pharmacokinetics	Mixing/Dosing/Other	Storage
Toujeo® (insulin glargine)	SoloStar® (300 units/ml) 1.5 ml pen Comes in package of 3 or 5 pens Needles Compatible with BD® Ultra-Fine pen needles	Onset of action 6 hours Duration of action 24+ hours Steady state is reached at ≥ 5 days Peak effect No peak	MIXING DO NOT MIX with other insulins DOSING Dosage will vary by patient The recommended starting dose of Toujeo® in patients with type 2 diabetes who are not currently treated with insulin is 0.2 units/kg once daily Toujeo® may be administered at any time during the day Toujeo® should be administered at the same time every day Toujeo® is a basal insulin In a multidose study, the glucose-lowering effect of Toujeo® was about 27% lower than that of an equivalent dose of Lantus® See insulin dosing for more OTHER Toujeo® should be clear and colorless Information on converting between Toujeo and other insulins - Click here	UNPUNCTURED, REFRIGERATED (Pens) Good until expiration date on product PUNCTURED (Pens) Do not refrigerate Pens are good for 42 days

Drug	Dosage form	Pharmacokinetics	Mixing/Dosing/Other	Storage
Levemir® (insulin detemir)	Vial (100 units/ml) 10 ml vial FlexPen® (100 units/ml) 3 ml pen Comes in package of 5 FlexTouch® (100 units/ml) 3 ml pen Comes in package of 5 FlexTouch® pen button maintains the same extension at all doses Needles Uses NovoFine® and NovoTwist® pen needles BD® Ultra-fine needles are compatible with FlexPen®	Onset of action 1 - 3 hours Duration of action 6 - 24 hours Levemir's duration of action depends on the dose Dose (units/kg) Duration (hours) 0.1 6 0.2 12 0.4 20 ≥0.8 22 - 24 Peak effect Varies	MIXING DO NOT MIX with other insulins DOSING Dosage will vary by patient Levemir® may be dosed once- or twice-daily Once-daily doses should be administered with the evening meal or at bedtime With twice-daily dosing, the evening dose can be administered with the evening meal, at bedtime, or 12 hours after the morning dose The recommended starting dose of Levemir® in type 2 diabetics is 10 Units (or 0.1-0.2 Units/kg) given once daily in the evening or divided into a twice-daily regimen Levemir® is a basal insulin See insulin dosing for more OTHER Levemir® should be clear and colorless Information on converting between Levemir® and other insulins - Click here	UNPUNCTURED, REFRIGERATED (Vials, Pens) Good until expiration date on product UNPUNCTURED, ROOM TEMP (Vials) Good for 42 days UNPUNCTURED, ROOM TEMP (Pens) Good for 42 days PUNCTURED (Vials) Refrigerated or room temp Good for 42 days PUNCTURED (Pens) Do not refrigerate Keep at room temperature Good for 42 days

Drug	Dosage form	Pharmacokinetics	Mixing/Dosing/Other	Storage
Tresiba® (insulin degludec)	FlexTouch® Comes in 2 strengths: U-100 - 100 units/ml U-200 - 200 units/ml Pens contain 3 mls U-100 comes in package of 5 pens U-200 comes in package of 3 pens Needles Uses NovoFine®, NovoFine® Plus, and NovoTwist® pen needles Cobination product - Xultophy®(Liraglutide + insulin degludec) 100 units of insulin and 3.6 mg of liraglutide/ml Comes in 3 ml pens sold in packages of 5 Liraglutide is a GLP-1 analog	Onset of action 1 - 3 hours Duration of action 24+ hours Peak effect No peak	MIXING DO NOT MIX with other insulins DOSING Dosage will vary by patient Tresiba is dosed once daily and may be given at any time during the day The recommended starting dose of Tresiba in insulin-naïve type 2 diabetics is 10 units once daily Tresiba is a basal insulin See insulin dosing for more See Xultophy for information on Xultophy dosing OTHER Tresiba should be clear and colorless Information on converting between Tresiba and other insulins - Click here	UNPUNCTURED, REFRIGERATED (Pens) Good until expiration date on product UNPUNCTURED, ROOM TEMP (Pens) Pens are good for 56 days PUNCTURED (Pens) Do not refrigerate Keep at room temperature Good for 56 days

Drug	Dosage form	Pharmacokinetics	Mixing/Dosing/Other	Storage
Humalog® Mix 75/25 25% insulin lispro/ 75% insulin lispro protamine Humalog® Mix 50/50 50% insulin lispro/ 50% insulin lispro protamine	Vial (100 units/ml) 10 ml vial KwikPen® (100 units/ml) 3 ml pen Comes in package of 5 Needles Compatible with BD® pen needles	Onset of action 10 - 30 minutes Duration of action up to 20 hours Peak effect 1 - 4 hours	MIXING DO NOT MIX with other insulins DOSING Dosage will vary by patient Dosage should be given within 15 minutes of a meal See insulin dosing for more OTHER Humalog® Mix should be resuspended before use (see instructions with product) Humalog® Mix should appear uniformly cloudy with no particulate matter after resuspending	UNPUNCTURED, REFRIGERATED (Vials, Pens) Good until expiration date on product UNPUNCTURED, ROOM TEMP (Vials) Good for 28 days UNPUNCTURED, ROOM TEMP (Pens) Good for 10 days PUNCTURED (Vials) Refrigerated or room temp Good for 28 days PUNCTURED (Pens) Do not refrigerate Keep at room temperature Good for 10 days

Drug	Dosage form	Pharmacokinetics	Mixing/Dosing/Other	Storage
Humulin® 70/30 70% NPH/ 30% regular	Vial (100 units/ml) 10 ml vial KwikPen® (100 units/ml) 3 ml pen Comes in package of 5 Needles Compatible with BD® pen needles	Onset of action 30 - 60 minutes Duration of action up to 20 hours Peak effect 3 - 12 hours	MIXING DO NOT MIX with other insulins DOSING Dosage will vary by patient Doses should be given 30 - 45 minutes before a meal See insulin dosing for more OTHER Humulin® 70/30 should be resuspended before use (see instructions with product) Humulin® 70/30 should appear uniformly cloudy with no particulate matter after resuspending	UNPUNCTURED, REFRIGERATED (Vials, Pens) Good until expiration date on product UNPUNCTURED, ROOM TEMP (Vials) Good for 31 days UNPUNCTURED, ROOM TEMP (Pens) Good for 10 days PUNCTURED (Vials) Refrigerated or room temp Good for 31 days PUNCTURED (Pens) Do not refrigerate Keep at room temperature Good for 10 days

Drug	Dosage form	Pharmacokinetics	Mixing/Dosing/Other	Storage
Novolin® 70/30 70% NPH/ 30% regular	Vial (100 units/ml) 10 ml vial	Onset of action 30 - 60 minutes Duration of action up to 20 hours Peak effect 3 - 12 hours	MIXING DO NOT MIX with other insulins DOSING Dosage will vary by patient Doses should be given 30 - 45 minutes before a meal See insulin dosing for more OTHER Novolin® 70/30 should be resuspended before use (see instructions with product) Novolin® 70/30 should appear uniformly cloudy with no particulate matter after resuspending	UNPUNCTURED, REFRIGERATED (Vials) Good until expiration date on product UNPUNCTURED, ROOM TEMP (Vials) Vials are good for 42 days PUNCTURED (Vials) Refrigerated or room temp Vials are good for 42 days

Drug	Dosage form	Pharmacokinetics	Mixing/Dosing/Other	Storage
Novolog® Mix 70/30 70% insulin aspart protamine/ 30% insulin aspart	Vial (100 units/ml) 10 ml vial FlexPen® (100 units/ml) 3 ml pen Comes in package of 5 Needles Uses NovoFine® and NovoTwist® pen needles BD® Ultra-fine needles are compatible with FlexPen®	Onset of action 10 - 30 minutes Duration of action up to 20 hours Peak effect 1 - 4 hours	MIXING DO NOT MIX with other insulins DOSING Dosage will vary by patient Doses should be given within 15 minutes of a meal See insulin dosing for more OTHER Novolog® Mix should be resuspended before use (see instructions with product) Novolog® Mix should appear uniformly cloudy with no particulate matter after resuspending	UNPUNCTURED, REFRIGERATED (Vials, Pens) Good until expiration date on product UNPUNCTURED, ROOM TEMP (Vials) Good for 28 days UNPUNCTURED, ROOM TEMP (Pens) Good for 14 days PUNCTURED (Vials) Refrigerated or room temp Vials are good for 28 days PUNCTURED (Pens) Do not refrigerate Pens are good for 14 days

Drug	Dosage form	Pharmacokinetics	Mixing/Dosing/Other	Storage
Ryzodeg® 70/30 70% insulin degludec/ 30% insulin aspart	FlexTouch® (100 units/ml) Pens contain 3 ml Comes in package of 5 pens Needles Uses NovoFine® and NovoTwist® pen needles	Onset of action 10 - 30 minutes Duration of action 24+ hours Peak effect 1/2 - 2 hours	MIXING DO NOT MIX with other insulins DOSING Dosage will vary by patient May be given once or twice daily with any main meal A rapid- or short-acting insulin may be given at other meals if needed Doses should be given within 15 minutes of a meal See insulin dosing for more OTHER Ryzodeg should be clear and colorless	UNPUNCTURED, REFRIGERATED (Pens) Good until expiration date on product UNPUNCTURED, ROOM TEMP (Pens) Good for 28 days PUNCTURED (Pens) Do not refrigerate Pens are good for 28 days

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